Year 2018, Volume 3, Issue 1

Year : 2018
Volume : 3
Issue : 1
Authors : Olga Vyacheslavovna RUDNEVA, Liudmila Alexandrovna NAPISANOVA, Vera Kuzminichna BEREZHKO
Abstract : Trichinosis is a parasitic disease caused by roundworms of the Trichinella type. Geographic distribution - worldwide. Nematodes of the genus Trichinella are one of the most widespread zoonotic pathogens on the world, and they can still cause major public health problems in many parts of the world. In our study we evaluated the protective effect of azoximeri bromidum in experimental trichinosis of mice. The azoximeri bromidum, is a polymer, a combined innovative product with immunomodulating, detoxifying, and antioxidative action, it is part of the Russian influenza vaccine. An assay was carried out on 20 white outbred mice weighting 16-18 g, divided into 2 groups of 10 animals in each. The first group was injected with azoximeri bromidum; the second group was injected with 0.9% NaCl. The drug was injected twice with an interval of 48 hours intramuscularly in a dose of 0,004 mg/mouse. After 48 hours the mice were infected by Trichinella spiralis larvae in a dose of 80±5 larvae/mouse. Analysis of the data indicates that in the experiment the application of this drug had significant protective effect. The number of T. spiralis larvae detected in animals was 142.5±11.1 larvae/mouse, respectively. This was 31.5 times less than in the mice of control group (4485 ± 430.6 larvae/mouse). Based on this, we consider it is expedient to continue the study of this immunostimulator drug in the complex immunoprophylaxis of trichinosis.
For citation : Rudneva, O. V., Napisanova, L. A., Berezhko, V. K. (2018). Azoximeri bromidum - protective action of immunostimulator drug in experimental trichinosis of mice. AGROFOR International Journal, Volume 3. Issue No. 1. pp. 99-105. DOI: 10.7251/AGRENG1801099R
Keywords : immunostimulator drugs, Trihinella spiralis, immunoprophylaxis, immunomodulators, azoximeri bromidum, mice
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